PDK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16878324	Proteintech 18262-1-AP-20UL	20 μL
16868324	Proteintech 18262-1-AP-150UL	150 μL

Description

This antibody is specific to PDK1.

Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Specifications

• Antigen: PDK1
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q15118, Q63065, Q8BFP9
• Gene ID (Entrez): 116551, 228026, 5163
• Immunogen: PDK1 Fusion Protein Ag13121
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: PDK1

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: PDH kinase 1, PDHK1, PDK1, Pyruvate dehydrogenase kinase isoform 1
• Gene Symbols: PDK1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody