PF 04671536 hydrochloride

Potent and selective PDE8B/8A inhibitor

Brand:  Tocris 6024/5

Product Code. 18766378

Description

PF 04671536 hydrochloride is a potent and selective PDE8B/8A inhibitor (IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.

Specifications

• Chemical Name or Material: 5-Methyl-3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine hydrochloride
• Assay Percent Range: >98%
• Molecular Formula: C₁₄H₁₈N₈OS.HCl

• CAS: 1305116-67-9
• Quantity: 5 mg
• Formula Weight: Observed MW: 382.87