Thermo Scientific™ Pierce™ DSP, No-Weigh™ Format

Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

Brand:  Thermo Scientific™ 22585

Product Code. 10731945

Description

Thermo Scientific™ Pierce DSP Crosslinker (Lomant's Reagent) is an amine-reactive crosslinker with NHS-ester reactive ends and a cleavable disulfide bond in its spacer arm.

Highlights:

• Cleavable by reducing agents
• Membrane-permeable
• Acylate in aqueous or organic media within two minutes at room temperature
• Four- to five-hour half-life of ester at pH 7.0
• Reactive groups: NHS ester (homobifunctional)
• Reactive toward: amino groups

Specifications

• Chemical Reactivity: Amine-Amine
• Description: DSP
• PEGylated: No
• Content And Storage: Upon receipt store desiccated at 4°C.
• Shipping Condition: Ambient
• Labeling Method: Chemical Labeling
• Reactive Moiety: NHS Ester
• Form: Powder
• Solubility: DMF, DMSO
• Water Soluble: No

• Cleavable: By Thiols
• Molecular Weight (g/mol): 404.42
• Spacer Arm Length: 12.0 Å
• Cell Permeability: Yes
• Product Line: Pierce™
• Crosslinker Type: Homobifunctional
• Spacer: Medium (10 to 30 Å)
• Quantity: 1 g
• Format: Standard, Single-use, Premium-grade
• Product Type: Crosslinker

Safety and Handling

Product Identifier

• DSP (dithiobis(succinimidyl propionate)), Lomant's Reagent

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P264-Wash hands thoroughly after handling.
• P271-Use only outdoors or in a well-ventilated area.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.
• P403+P233-Store in a well-ventilated place. Keep container tightly closed.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : disuccinimido dithiobispropionate

For Research Use Only. Not for use in diagnostic procedures.