Tocris Bioscience™ Pyr 10

Selective TRPC3 inhibitor

Brand:  Tocris Bioscience™ 6941/50

Product Code. 18768946

Description

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.

Specifications

• Chemical Name or Material: N-[4-[3,5-bis(Trifluoromethyl)-1 H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
• Quantity: 50 mg
• Molecular Formula: C₁₈H₁₃F₆N₃O₂S

• CAS: 1315323-00-2
• Target: TRPC Channel Blockers
• Purity: 0.98