Invitrogen™ RANKL (Soluble) Human ELISA Development Kit (ABTS), PeproTech®, PeproTech®

ELISA

Brand:  Invitrogen™ 900-M142

Product Code. 17838925

Description

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Specifications

• Accession Number: O14788
• Gene ID (Entrez): 8600
• Quantity: 2 x 96 Tests
• Storage Requirements: Refer to product documentation for component specific storage temperature.

• Product Type: ELISA
• Gene Symbol: TNFSF11
• Regulatory Status: RUO
• Target: Human