Gibco™ Rat IL-15 Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Product Code	Brand	Quantity
17874493	Gibco™ 400-24-100UG	100 μg
17834763	Gibco™ 400-24-10UG	10 μg
17814683	Gibco™ 400-24-1MG	1 mg
17864623	Gibco™ 400-24-250UG	250 μg
17824113	Gibco™ 400-24-2UG	2 μg
17834693	Gibco™ 400-24-500UG	500 μg

Description

IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.

Specifications

• Accession Number: P97604
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 13.5
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15
• Specific Reactivity: Rat
• Recombinant: Recombinant
• Form: Lyophilized

• For Use With (Application): Functional Assay
• Gene ID (Entrez): 25670
• Name: Rat IL-15
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: IL15
• Conjugate: Unconjugated
• Sequence: MNWIDVRYDL EKIESLIQFI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VIESGCKECE ELEERNFTEF LQSFIHIVQM FINTS
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.