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Gibco™ Rat TPO (Thrombopoietin) Recombinant Protein, PeproTech®
E. coli Recombinant Protein
Brand: Gibco™ 400-34-500UG
This item is not returnable.
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Description
Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.Specifications
P49745 | |
protein with no preservative | |
18.7 | |
500 μg | |
-20°C | |
<1 EU/μg | |
THPO | |
Unconjugated | |
SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
Functional Assay | |
108348162, 81811 | |
Rat TPO (Thrombopoietin) | |
E. coli | |
RUO | |
C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX | |
Rat | |
Recombinant | |
Lyophilized |