Gibco™ Rat TPO (Thrombopoietin) Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Product Code	Brand	Quantity
17864523	Gibco™ 400-34-100UG	100 μg
17803913	Gibco™ 400-34-10UG	10 μg
17894383	Gibco™ 400-34-1MG	1 mg
17884383	Gibco™ 400-34-250UG	250 μg
17863833	Gibco™ 400-34-2UG	2 μg
17834563	Gibco™ 400-34-500UG	500 μg

Description

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.

Specifications

• Accession Number: P49745
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 18.7
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX
• Specific Reactivity: Rat
• Recombinant: Recombinant
• Form: Lyophilized

• For Use With (Application): Functional Assay
• Gene ID (Entrez): 108348162, 81811
• Name: Rat TPO (Thrombopoietin)
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: THPO
• Conjugate: Unconjugated
• Sequence: SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.