STEMCELL Technologies SIS3

Activin/NODAL/TGF-β pathway inhibitor; Inhibits SMAD3

Brand:  STEMCELL Technologies 73964

Product Code. 17130302

Description

• SIS3 (specific inhibitor of SMAD3) is a cell-permeable selective inhibitor of transforming growth factor β1 (TGF-β1)-dependent SMAD3 phosphorylation (IC₅₀ = 3 μM) and SMAD3-mediated cellular signaling (Jinnin et al.) SIS3 has no effect on SMAD2, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), or phosphoinositide 3-kinases
• Facilitates the production of anterior ectoderm from mouse induced pluripotent stem cells (Oshima et al.)
• Inhibits myofibroblast differentiation of normal human dermal fibroblasts (Jinnin et al.)

Specifications

• CAS: 1009104-85-1
• Quantity: 1 mg
• Purity: ≥98%

• Synonym: Smad3 inhibitor
• Molecular Formula: C₂₈H₂₇N₃O₃