Streptomycin sulfate, Cell Culture Reagent, Thermo Scientific Chemicals

Description

Streptomycin sulfate, CAS # 3810-74-0, is the sulfate salt form of streptomycin, and an aminoglycoside with antibacterial activity. It also shows a protein synthesis inhibitory activity.

Inhibits initiation and causes misreading of rRNA in protein synthesis Streptomycin sulfate is used to study the mechanisms of streptomycin resistance. It is used to inhibit bacterial contamination in cell culture applications in association with penicillin. It is an antibiotic drug initially used for tuberculosis treatment. It inhibits protein synthesis by binding to 30S ribosomal subunit, which induces the misreading of the genetic code. It is involved in the initiation of translation of DNA, thereby results in death for a susceptible bacterium. Further, it controls bacterial and fungal diseases of certain fruit, vegetables, seed, ornamental crops and algae in ornamental ponds and aquaria

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Streptomycin sulfate is an aminoglycoside sulfate salt derived from Streptomyces griseus that shows antibacterial activity.

• It inhibits the initiation and causes misreading of rRNA in protein synthesis. This compound binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis.

Application

• Streptomycin sulfate can be used to study the mechanisms of streptomycin resistance

• This compound can be used in laboratory applications combined with penicillin to inhibit bacterial contamination in in vitro cell culture

• Streptomycin sulfate shows antibiotic activity against Mycobacterium tuberculosis

• This compound can be used as a protein synthesis inhibitor

• It acts against gram-negative and gram-positive bacteria

• Streptomycin sulfate also shows a fungicide activity

• It can be used to remove nucleic acids from a biological extract

Specifications

Chemical Identifiers

• CAS: 3810-74-0
• Molecular Formula: C42H84N14O36S3
• Molecular Weight (g/mol): 1457.376
• MDL Number: MFCD00037023
• InChI Key: QTENRWWVYAAPBI-FFCQDDOVSA-N
• PubChem CID: 124080941
• IUPAC Name: 2-[(1R,2S,3S,4S,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3S,4S,5S)-3-[(2R,3S,4R,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;2-[(1R,2S,3S,4R,5R,6R)-3-(
• SMILES: CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

• Type: Streptomycin Sulfate
• Physical Form: Powder
• Color: White
• Quantity: 100 g
• Beilstein: 3894995
• Merck Index: 14,8826
• Solubility Information: Soluble in water.
• Formula Weight: 728.69
• Grade: Cell Culture
• Chemical Name or Material: Streptomycin sulfate

Safety and Handling

Product Identifier

• Streptomycin sulfate, Cell Culture Reagent

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Reproductive toxicity Category 2
• Skin sensitiser Category 1

Hazard Statement

• H302-Harmful if swallowed.
• H317-May cause an allergic skin reaction.
• H361d-Suspected of damaging the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Streptomycin sulphate

RUO – Research Use Only