tert-Butyldimethylchlorosilane, 97%, Thermo Scientific Chemicals

Description

tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

Solubility
Soluble in chloroform and ethyl acetate. Insoluble in water.

Notes
Moisture sensitive. Store in cool place. Incompatible with bases, metals, oxidizing agents and alcohols.

Specifications

Chemical Identifiers

• CAS: 18162-48-6
• Molecular Formula: C6H15ClSi
• Molecular Weight (g/mol): 150.721
• MDL Number: MFCD00000501
• InChI Key: BCNZYOJHNLTNEZ-UHFFFAOYSA-N
• Synonym: tert-butyldimethylsilyl chloride, tert-butyldimethylchlorosilane, t-butyldimethylchlorosilane, tert-butylchlorodimethylsilane, tbdms chloride, tert-butyl chloro dimethylsilane, chloro-tert-butyldimethylsilane, silane, chloro 1,1-dimethylethyl dimethyl, tbscl, t-butyldimethylsilyl chloride
• PubChem CID: 28928
• ChEBI: CHEBI:85071
• IUPAC Name: tert-butyl-chloro-dimethylsilane
• SMILES: CC(C)(C)[Si](C)(C)Cl

• Boiling Point: 124°C to 126°C
• Melting Point: 86°C to 89°C
• Quantity: 25 g
• Linear Formula: (CH₃)₃CSi(CH₃)₂Cl
• UN Number: UN2925
• Beilstein: 505999
• Flash Point: 22°C (72°F)
• Solubility Information: Soluble in chloroform and ethyl acetate. Insoluble in water.
• Formula Weight: 150.73
• Percent Purity: 97%
• Odor: Pungent
• Sensitivity: Moisture sensitive
• Density: 0.81
• Chemical Name or Material: tert-Butyldimethylchlorosilane

Safety and Handling

Product Identifier

• tert-Butyldimethylchlorosilane

Signal Word

• Danger

Hazard Category

• LONG-TERM AQUATIC HAZARD Chronic 2
• Serious eye damage/eye irritation Category 1
• Flammable solid Category 2
• Skin corrosion/irritation Category 1 A

Hazard Statement

• H228-Flammable solid.
• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H411-Toxic to aquatic life with long lasting effects.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : chloro(1,1-dimethylethyl)dimethyl-silane

RUO – Research Use Only