tert-Butyldimethylchlorosilane, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11474364	Thermo Scientific Alfa Aesar A13064.06	5 g
11484364	Thermo Scientific Alfa Aesar A13064.14	25 g
11494364	Thermo Scientific Alfa Aesar A13064.22	100 g

Description

tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.

Solubility
Soluble in chloroform and ethyl acetate. Insoluble in water.

Notes
Moisture sensitive. Store in cool place. Incompatible with bases, metals, oxidizing agents and alcohols.

Chemical Identifiers

• CAS: 18162-48-6
• Molecular Weight (g/mol): 150.721
• InChI Key: BCNZYOJHNLTNEZ-UHFFFAOYSA-N
• PubChem CID: 28928
• IUPAC Name: tert-butyl-chloro-dimethylsilane

• Molecular Formula: C6H15ClSi
• MDL Number: MFCD00000501
• Synonym: tert-butyldimethylsilyl chloride, tert-butyldimethylchlorosilane, t-butyldimethylchlorosilane, tert-butylchlorodimethylsilane, tbdms chloride, tert-butyl chloro dimethylsilane, chloro-tert-butyldimethylsilane, silane, chloro 1,1-dimethylethyl dimethyl, tbscl, t-butyldimethylsilyl chloride
• ChEBI: CHEBI:85071
• SMILES: CC(C)(C)[Si](C)(C)Cl

Specifications

• Boiling Point: 124°C to 126°C
• CAS: 18162-48-6
• Linear Formula: (CH₃)₃CSi(CH₃)₂Cl
• UN Number: UN2925
• Flash Point: 22°C (72°F)
• Solubility Information: Soluble in chloroform and ethyl acetate. Insoluble in water.
• SMILES: CC(C)(C)[Si](C)(C)Cl
• Molecular Weight (g/mol): 150.721
• ChEBI: CHEBI:85071
• Percent Purity: 97%
• Sensitivity: Moisture sensitive
• Chemical Name or Material: tert-Butyldimethylchlorosilane

• Melting Point: 86°C to 89°C
• Molecular Formula: C6H15ClSi
• MDL Number: MFCD00000501
• Beilstein: 505999
• Synonym: tert-butyldimethylsilyl chloride, tert-butyldimethylchlorosilane, t-butyldimethylchlorosilane, tert-butylchlorodimethylsilane, tbdms chloride, tert-butyl chloro dimethylsilane, chloro-tert-butyldimethylsilane, silane, chloro 1,1-dimethylethyl dimethyl, tbscl, t-butyldimethylsilyl chloride
• InChI Key: BCNZYOJHNLTNEZ-UHFFFAOYSA-N
• IUPAC Name: tert-butyl-chloro-dimethylsilane
• PubChem CID: 28928
• Formula Weight: 150.73
• Odor: Pungent
• Density: 0.81

Safety and Handling

GHS H Statement
H228-H314-H318
Flammable solid.
Causes severe skin burns and eye damage.
Causes serious eye damage.

P210-P240-P241-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c

H228-H314-H335

missing translation for 'dotInformation' : Hazard Class: 8; Packaging Group: I

missing translation for 'einecsNumber' : 242-042-4

missing translation for 'rtecsNumber' : VV2000000

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

Product Identifier

• tert-Butyldimethylchlorosilane

Signal Word

• Danger

Hazard Category

• LONG-TERM AQUATIC HAZARD Chronic 2
• Serious eye damage/eye irritation Category 1
• Flammable solid Category 2
• Skin corrosion/irritation Category 1 A

Hazard Statement

• H228-Flammable solid.
• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H411-Toxic to aquatic life with long lasting effects.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Chloro(1,1-dimethylethyl)dimethyl-silane

RUO – Research Use Only