Tocris Bioscience™ TM2 TEAD inhibitor

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

Brand:  Tocris Bioscience™ 7917/10

Product Code. 18706075

Description

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.

Specifications

• Chemical Name or Material: 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
• Quantity: 10 mg
• Molecular Formula: C₂₆H₃₃N₃O₃

• CAS: 1008768-41-9
• Target: YAP1
• Purity: 0.98