Trifluoroacetic acid, 99%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11372486	Thermo Scientific Alfa Aesar L06374.AC	25 mL
11382486	Thermo Scientific Alfa Aesar L06374.AE	100 mL
11392486	Thermo Scientific Alfa Aesar L06374.AP	500 mL

Description

The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Solubility
Miscible with ether, acetone, ethanol, benzene, hexane and carbon tetrachloride.

Notes
Trifluoroacetic acid (TFA) is a stable, hygroscopic, volatile and low-boiling organic acid. Storage in a cool place is recommended.

Chemical Identifiers

• CAS: 76-05-1
• Molecular Weight (g/mol): 114.02
• InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N
• PubChem CID: 6422
• IUPAC Name: trifluoroacetic acid

• Molecular Formula: C2HF3O2
• MDL Number: MFCD00004169
• Synonym: trifluoroacetic acid, perfluoroacetic acid, trifluoroethanoic acid, trifluoroacetic acid, acetic acid, trifluoro, trifluoroaceticacid, cf3cooh, trifluoro acetic acid, trifluoro-acetic acid, kyselina trifluoroctova
• ChEBI: CHEBI:45892
• SMILES: OC(=O)C(F)(F)F

Specifications

• CAS: 76-05-1
• Boiling Point: 72°C to 73°C
• Linear Formula: CF₃CO₂H
• UN Number: UN2699
• Merck Index: 14,9681
• Solubility Information: Miscible with ether,acetone,ethanol,benzene,hexane and carbon tetrachloride.
• SMILES: OC(=O)C(F)(F)F
• Molecular Weight (g/mol): 114.02
• ChEBI: CHEBI:45892
• Percent Purity: 99%
• Odor: Pungent
• Sensitivity: Hygroscopic

• Melting Point: -15°C
• Molecular Formula: C2HF3O2
• MDL Number: MFCD00004169
• Beilstein: 742035
• Synonym: trifluoroacetic acid, perfluoroacetic acid, trifluoroethanoic acid, trifluoroacetic acid, acetic acid, trifluoro, trifluoroaceticacid, cf3cooh, trifluoro acetic acid, trifluoro-acetic acid, kyselina trifluoroctova
• InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N
• IUPAC Name: trifluoroacetic acid
• PubChem CID: 6422
• Formula Weight: 114.02
• Density: 1.48
• Refractive Index: 1.284
• Chemical Name or Material: Trifluoroacetic acid

Safety and Handling

GHS H Statement
H314-H332
Causes severe skin burns and eye damage.
Harmful if inhaled.

P234-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P390-P501c

H290-H314-H332-H335

missing translation for 'dotInformation' : Transport Hazard Class: 8; Packing Group: I; Proper Shipping Name: TRIFLUOROACETIC ACID

missing translation for 'einecsNumber' : 200-929-3

missing translation for 'rtecsNumber' : AJ9625000

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

Product Identifier

• Trifluoroacetic acid

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• LONG-TERM AQUATIC HAZARD Chronic 3
• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 A

Hazard Statement

• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H332-Harmful if inhaled.
• H412-Harmful to aquatic life with long lasting effects.
• EUH071-Corrosive to the respiratory tract.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Trifluoroacetic acid

RUO – Research Use Only