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Trifluoroacetic Acid

Trifluoroacetic Acid

Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.

Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:

  • Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
  • Dissolves protein when mixed with liquid SO2
  • Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
  • Can remove the t-butoxycarbonyl protecting group in organic synthesis
  • At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
  • For acid-stable materials, can be a solvent for NMR spectroscopy
  • Acts as a calibrant in mass spectrometry
  • Used to produce trifluoroacetate salts
  • An ingredient in adhesives, sealants, paints, and coatings

 

When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.

Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.

TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.

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1 – 15 of 31 results
1

Trifluoroacetic Acid, 99+%, for HPLC, Fisher Chemical™

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
2

Trifluoroacetic acid, 99+%, for HPLC, Thermo Scientific Chemicals

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: 2,2,2-trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name 2,2,2-trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
3

Trifluoroacetic acid, 99.5%, for biochemistry, Thermo Scientific Chemicals

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
4

Trifluoroacetic Acid, Optima™ LC/MS Grade, Fisher Chemical™

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
5

Trifluoroacetic acid, 99%, extra pure, Thermo Scientific Chemicals

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
6

Thermo Scientific™ Pierce™ Trifluoroacetic Acid (TFA), Sequencing grade

Bottles of 99.5%-pure TFA (MW 114.02, CAS 76-05-01) liquid (sold by weight); for HPLC use as an ion-pairing agent in reverse-phase peptide separations.

Name Note Trifluoroacetic Acid (TFA)
Percent Purity 99.5% (TFA)
Physical Form Liquid
Recommended Storage Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, between the following temperatures: 20 to 25°C.
7

Trifluoroacetic acid, 99%, Thermo Scientific Chemicals

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
8

Trifluoroacetic acid, HPLC Grade, 99.5+%, Thermo Scientific Chemicals

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: 2,2,2-trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name 2,2,2-trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
11

Trifluoroacetic acid, 99%, Thermo Scientific Chemicals

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
12

Trifluoroacetic acid, 99.5+%, Thermo Scientific Chemicals

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

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PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
13

Trifluoroacetic Acid, HPLC Grade, J.T. Baker™

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2
14

Trifluoroacetic acid, Reagent Grade, 99%, Honeywell™

CAS: 76-05-1 Molecular Formula: C2HF3O2 Molecular Weight (g/mol): 114.02 MDL Number: MFCD00004169 InChI Key: DTQVDTLACAAQTR-UHFFFAOYSA-N Synonym: trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova PubChem CID: 6422 ChEBI: CHEBI:45892 IUPAC Name: trifluoroacetic acid SMILES: OC(=O)C(F)(F)F

PubChem CID 6422
CAS 76-05-1
Molecular Weight (g/mol) 114.02
ChEBI CHEBI:45892
MDL Number MFCD00004169
SMILES OC(=O)C(F)(F)F
Synonym trifluoroacetic acid,perfluoroacetic acid,trifluoroethanoic acid,trifluoroacetic acid,acetic acid, trifluoro,trifluoroaceticacid,cf3cooh,trifluoro acetic acid,trifluoro-acetic acid,kyselina trifluoroctova
IUPAC Name trifluoroacetic acid
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Molecular Formula C2HF3O2