Invitrogen™ Human ULK1, GST Tag Recombinant Protein

ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. Recombinant human ULK1 (1-649) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Product Code	Brand	Quantity
15431234	Invitrogen™ PV6430	10 μg
15409053	Invitrogen™ PV6431	100 μg
15419053	Invitrogen™ PV6432	1 mg

Description

The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.

• Validated in LanthaScreen™ Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Specifications

• Gene Alias: ATG1, UNC51, Unc51.1, FLJ38455
• Species: Human
• Protein Tag: GST Tag

• Protein Length: aa 1-649
• Recombinant: Recombinant