Tocris Bioscience™ XL 184

Potent VEGFR inhibitor; also inhibits other RTKs

Brand:  Tocris Bioscience™ 5422/10

Product Code. 18716229

Description

XL 184 is a potent VEGFR inhibitor (IC50 = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.

Specifications

• Purity: >98%
• Quantity: 10 mg
• Molecular Weight (g/mol): 501.51

• Gene Alias: Cabozantinib, BMS 907351
• Product Type: XL 184
• Inhibitors: XL 184

For Research Use Only