4EGI-1, Tocris Bioscience™

Description

Inhibits eIF4E:eIF4G subunit interaction

Inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Specifications

Chemical Identifiers

• CAS: 315706-13-9
• Molecular Formula: C18H12Cl2N4O4S
• Molecular Weight (g/mol): 451.28
• MDL Number: MFCD02330020
• InChI Key: KFRKRECSIYXARE-UHFFFAOYSA-N
• Synonym: 2e-2-2-4-3,4-dichlorophenyl-1,3-thiazol-2-yl hydrazin-1-ylidene-3-2-nitrophenyl propanoic acid, 2z-2-4-3,4-dichlorophenyl-1,3-thiazol-2-yl hydrazinylidene-3-2-nitrophenyl propanoic acid, 2-4-3,4-dichlorophenyl thiazol-2 3h-ylidene hydrazono-3-2-nitrophenyl propanoic acid
• PubChem CID: 6911989
• IUPAC Name: 2-{2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazin-1-ylidene}-3-(2-nitrophenyl)propanoic acid
• SMILES: OC(=O)C(CC1=CC=CC=C1[N+]([O-])=O)=NNC1=NC(=CS1)C1=CC(Cl)=C(Cl)C=C1

• Quantity: 50 mg
• Formula Weight: 451.28
• Percent Purity: >98%
• Chemical Name or Material: Protein-synthesizing GTPase Compounds