ACT 335827, Tocris Bioscience™

Description

Potent and selective OX1 antagonist

Potent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.

Specifications

Chemical Identifiers

• CAS: 1354039-86-3
• Molecular Formula: C31H38N2O5
• Molecular Weight (g/mol): 518.654
• InChI Key: HXHOBPVRRPCTLG-SETSBSEESA-N
• Synonym: compound 9 pmid: 23589487, 2r-2-1s-1-3,4-dimethoxyphenyl methyl-6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl-2-phenyl-n-propan-2-ylacetamide, ar,1s-1-3,4-dimethoxyphenyl methyl-3,4-dihydro-6,7-dimethoxy-n-1-methylethyl-a-phenyl-2 1h-isoquinolineacetamide, r-2-s-1-3,4-dimethoxybenzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2 1h-yl-n-isopropyl-2-phenylacetamide
• PubChem CID: 54765113
• IUPAC Name: (2R)-2-[(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenyl-N-propan-2-ylacetamide
• SMILES: CC(C)NC(=O)C(C1=CC=CC=C1)N2CCC3=CC(=C(C=C3C2CC4=CC(=C(C=C4)OC)OC)OC)OC

• Quantity: 50 mg
• Formula Weight: 518.64
• Chemical Name or Material: ACT 335827