Chloromethyl chloroformate, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11317476	Thermo Scientific Alfa Aesar L09527.09	10 g
11327476	Thermo Scientific Alfa Aesar L09527.18	50 g

Description

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

Solubility
Slightly miscible with water.

Notes
Incompatible with oxidizing agents and water.

Chemical Identifiers

• CAS: 22128-62-7
• Molecular Weight (g/mol): 128.936
• InChI Key: JYWJULGYGOLCGW-UHFFFAOYSA-N
• PubChem CID: 62754
• SMILES: C(OC(=O)Cl)Cl

• Molecular Formula: C2H2Cl2O2
• MDL Number: MFCD00077688
• Synonym: chloromethyl chloroformate, chloromethylchloroformate, chloroformic acid chloromethyl ester, carbonochloridic acid, chloromethyl ester, palite, chlormethylchlorformiat, clco2ch2cl, chlormethylchlorocarbonat, chloromethyl choroformate, choromethyl chloroformate
• IUPAC Name: chloromethyl carbonochloridate

Specifications

• CAS: 22128-62-7
• Density: 1.465
• Flash Point: 95°C (203°F)
• Molecular Formula: C2H2Cl2O2
• Refractive Index: 1.4295
• UN Number: UN2745
• Sensitivity: Moisture sensitive
• Solubility Information: Slightly miscible with water.
• SMILES: C(OC(=O)Cl)Cl
• Molecular Weight (g/mol): 128.936
• Formula Weight: 128.94
• Chemical Name or Material: Chloromethyl chloroformate

• Melting Point: <-20°C
• Boiling Point: 107°C to 108°C
• Odor: Acrid
• Linear Formula: ClCO₂CH₂Cl
• MDL Number: MFCD00077688
• Beilstein: 506426
• Synonym: chloromethyl chloroformate, chloromethylchloroformate, chloroformic acid chloromethyl ester, carbonochloridic acid, chloromethyl ester, palite, chlormethylchlorformiat, clco2ch2cl, chlormethylchlorocarbonat, chloromethyl choroformate, choromethyl chloroformate
• InChI Key: JYWJULGYGOLCGW-UHFFFAOYSA-N
• IUPAC Name: chloromethyl carbonochloridate
• PubChem CID: 62754
• Percent Purity: 97%

Safety and Handling

GHS H Statement
H331-H314-H318-H302
Toxic if inhaled.
Causes severe skin burns and eye damage.
Causes serious eye damage.
Harmful if swallowed.

P260-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

H302-H314-H330-H335

missing translation for 'dotInformation' : Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: CHLOROMETHYL CHLOROFORMATE

missing translation for 'einecsNumber' : 244-793-3

missing translation for 'tsca' : No

Recommended Storage : Keep cold

RUO – Research Use Only