Cycloheximide, Tocris Bioscience™

Description

Inhibitor of protein synthesis

Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Also inhibits ferroptosis. Antifungal antibiotic. Exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.16 μM).

Specifications

• CAS: 66-81-9
• Molecular Formula: C15H23NO4
• MDL Number: MFCD00082346
• Quantity: 100 mg
• Synonym: cycloheximide, actidione, cycloheximide, naramycin a, kaken, actidion, actidone, hizarocin, naramycin, neocycloheximide
• InChI Key: YPHMISFOHDHNIV-QTEFRXOUNA-N
• SMILES: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1
• IUPAC Name: 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
• Molecular Weight (g/mol): 281.35
• PubChem CID: 6197
• ChEBI: CHEBI:27641
• Formula Weight: 281.35
• Percent Purity: >97%
• Chemical Name or Material: Cycloheximide