Doxorubicin Hydrochloride, Fisher BioReagents

Product Code	Brand	Quantity	Packaging
10512955	Fisher BioReagents BP2516-1	1 mg	Amber Glass
11413074	Fisher BioReagents BP2516-5	5 mg	Amber Glass
10133293	Fisher BioReagents BP2516-10	10 mg	Amber Glass
10767945	Fisher BioReagents BP2516-50	50 mg	Amber Glass

Description

Doxorubicin Hydrochloride

Doxorubicin HCL is a chemotherapeutic agent. Antitumor, immunosuppressive, and antibiotic agent. It blocks RNA polymerase and reverse transcriptase. Also inhibits nucleic acid synthesis.

Chemical Identifiers

• CAS: 25316-40-9
• Molecular Weight (g/mol): 579.98
• InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N
• PubChem CID: 129626538
• SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O

• Molecular Formula: C27H30ClNO11
• MDL Number: MFCD00077757,MFCD00077757,MFCD00941448
• Synonym: doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs
• IUPAC Name: (7R,9R)-7-[(2S,4R,5R,6R)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

Specifications

• CAS: 25316-40-9
• Melting Point: 216°C
• Assay Percent Range: (by HPLC): ≥95%
• MDL Number: MFCD00077757,MFCD00077757,MFCD00941448
• Synonym: doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs
• InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N
• IUPAC Name: (7R,9R)-7-[(2S,4R,5R,6R)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
• PubChem CID: 129626538
• Physical Form: Powder or Solid

• Decomposition Information: 216°C
• Color: Orange
• Molecular Formula: C27H30ClNO11
• Merck Index: 15, 3487
• Solubility Information: Soluble in water
• SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
• Molecular Weight (g/mol): 579.98
• Formula Weight: 580
• Chemical Name or Material: Doxorubicin Hydrochloride

Safety and Handling

WARNING!

Emergency Overview
May cause cancer. Risk of serious damage to eyes. Irritating to respiratory system and skin. May cause heritable genetic damage. Possible risk of impaired fertility. Possible risk of harm to the unborn child. Use personal protective equipment. Use only under a chemical fume hood. Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required. Immediate medical attention is required. Move to fresh air.

NFPA

Health:2
Flammability:1
Instability:0

Recommended Storage : 2° to 8°C

Product Identifier

• Doxorubicin hydrochloride

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• Carcinogenicity Category 1B
• Serious eye damage/eye irritation Category 1
• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H318-Causes serious eye damage.
• H340-May cause genetic defects.
• H350-May cause cancer.
• H315-Causes skin irritation.
• H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
• H335-May cause respiratory irritation.
• H302-Harmful if swallowed.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.