Fumonisin B2, 96+%, Thermo Scientific Chemicals

Product Code. 10440931

Brand: Thermo Scientific Acros 328260010

Description

Fumonisin B2, CAS # 116355-84-1, is a diester of tricarballylic acid and is isolated from Fusarium.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fumonisin B2 is a fumonisin mycotoxin produced by the fungus Fusarium
• Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than B1 and can inhibit sphinganine-N-acetyltransferase (ceramide synthase)

Applications

• In vitro and in vivo studies have shown Fumonisin B2 can induce apoptosis
• It can inhibit de novo sphingolipid biosynthesis
• It is also considered an Aspergillus metabolite
• It shows cytotoxicity against a panel of seven rat hepatoma cell lines, and MDCK cell line
• It induces hepatocyte nodule formation, a marker of cancer initiation, in rats

Specifications

• CAS: 116355-84-1
• Assay Percent Range: 96+%
• Molecular Formula: C₃₄H₅₉NO₁₄·₃H₂O
• Quantity: 1 mg
• Synonym: fumonisin b2, 2r,2'r-1,2,3-propanetricarboxylic acid 1,1'-1s,2r-1-2s,9r,11s,12s-12-amino-4,9,11-trihydroxy-2-methyltridecyl-2-1r-1-methylpentyl-1,2-ethanediyl ester, 2s-2-2-5r,6r,7s,9s,16r,18s,19s-19-amino-6-3r-3,4-dicarboxybutanoyl oxy-16,18-dihydroxy-5,9-dimethylicosan-7-yl oxy-2-oxoethyl butanedioic acid
• Solubility Information: Solubility in water: .. Other solubilities: soluble in methanol
• InChI Key: UXDPXZQHTDAXOZ-FWPUDPCBSA-N
• SMILES: CCCCC(C)C(C(CC(C)CCCCCCC(CC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
• IUPAC Name: (2S)-2-[2-[(5R,6R,7S,9S,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-16,18-dihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid
• Molecular Weight (g/mol): 759.9
• PubChem CID: 71317007
• Formula Weight: 759.9
• Percent Purity: 96+%
• Chemical Name or Material: Fumonisin B2

Safety and Handling

Product Identifier

• Fumonisin B2

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Carcinogenicity Category 2
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H310-Fatal in contact with skin.
• H330-Fatal if inhaled.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H351-Suspected of causing cancer.
• H335-May cause respiratory irritation.
• H300-Fatal if swallowed.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.
• P361-Take off immediately all contaminated clothing.

SDS

RUO – Research Use Only