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Thermo Scientific™ Pierce™ NEM (N-ethylmaleimide)
Small, sulfhydryl-reactive (maleimide) compound to permanently block reduced cysteines of proteins or peptides to prevent disulfide bond formation.
Brand: Thermo Scientific™ 23030
This item is not returnable.
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Description
Thermo Scientific™ Pierce N-Ethylmaleimide (NEM) is a small compound that forms stable, covalent thioether bonds with sulfhydryls (e.g., reduced cysteines), enabling them to be permanently blocked to prevent disulfide bond formation.
Highlights:
- Forms covalent bonds with sulfhydryl groups at pH 6.5-7.5
- Reaction can be monitored by measuring the decrease in absorbance at 300nm
Specifications
| Thiol | |
| Unreactive Group | |
| Pierce™ | |
| Medium (10 to 30 Å) | |
| 25 g | |
| NEM |
| Upon receipt store at -20°C. | |
| Blocking Groups | |
| Maleimide | |
| Solid | |
| Water |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- N-Ethylmaleimide
Signal Word
- Danger
Hazard Category
- Acute toxicity Category 2
- Acute toxicity Category 3
- Serious eye damage/eye irritation Category 1
- Skin corrosion/irritation Category 1 B
- Skin sensitiser Category 1
Hazard Statement
- H300-Fatal if swallowed.
- H311-Toxic in contact with skin.
- H314-Causes severe skin burns and eye damage.
- H317-May cause an allergic skin reaction.
- H318-Causes serious eye damage.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P405-Store locked up.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : N-ethylmaleimide
Certificates
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Product Title
Thermo Scientific™ Pierce™ NEM (N-ethylmaleimide) > 25g
For Research Use Only. Not for use in diagnostic procedures.
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