TC-S 7005, Tocris Bioscience™

Description

Potent and selective PLK2 inhibitor

Potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Specifications

• CAS: 1082739-92-1
• Color: Cream
• Molecular Formula: C21H17N3O3
• Quantity: 10 mg
• Synonym: 2-amino-isoxazolopyridine, 9, 3-1,3-benzodioxol-5-yl-n-1s-1-phenylethyl-isoxazolo 5,4-c pyridin-5-amine, 3-2h-1,3-benzodioxol-5-yl-n-1s-1-phenylethyl pyrido 4,3-d 1,2 oxazol-5-amine
• InChI Key: DAAGOCSHXCDWDY-ZDUSSCGKSA-N
• SMILES: CC(C1=CC=CC=C1)NC2=NC=C3C(=C2)C(=NO3)C4=CC5=C(C=C4)OCO5
• IUPAC Name: 3-(1,3-benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-[1,2]oxazolo[5,4-c]pyridin-5-amine
• Molecular Weight (g/mol): 359.385
• PubChem CID: 24971422
• Formula Weight: 359.38
• Percent Purity: >98%
• Physical Form: Solid
• Chemical Name or Material: TC-S 7005