trans-4-Methoxycinnamic acid, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11461548	Thermo Scientific Alfa Aesar A13870.09	10 g
11471548	Thermo Scientific Alfa Aesar A13870.18	50 g
11481548	Thermo Scientific Alfa Aesar A13870.30	250 g

Description

Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.

Solubility
Soluble in ethanol, ethyl acetate and other organic solvents.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Chemical Identifiers

• CAS: 943-89-5
• Molecular Weight (g/mol): 178.19
• InChI Key: AFDXODALSZRGIH-QPJJXVBHSA-N
• PubChem CID: 699414
• SMILES: COC1=CC=C(\C=C\C(O)=O)C=C1

• Molecular Formula: C10H10O3
• MDL Number: MFCD00004398
• Synonym: 4-methoxycinnamic acid, p-methoxycinnamic acid, 3-4-methoxyphenyl acrylic acid, trans-4-methoxycinnamic acid, 4-methoxycinnamate, para-methoxycinnamic acid, o-methyl-p-coumaric acid, cinnamic acid, p-methoxy, e-3-4-methoxyphenyl acrylic acid, e-3-4-methoxyphenyl-2-propenoic acid
• IUPAC Name: (E)-3-(4-methoxyphenyl)prop-2-enoic acid

Specifications

• CAS: 943-89-5
• Molecular Formula: C10H10O3
• Beilstein: 510468
• Solubility Information: Soluble in ethanol,ethyl acetate and other organic solvents.
• SMILES: COC1=CC=C(\C=C\C(O)=O)C=C1
• Molecular Weight (g/mol): 178.19
• Formula Weight: 178.19
• Chemical Name or Material: trans-4-Methoxycinnamic acid

• Melting Point: 171°C to 175°C
• MDL Number: MFCD00004398
• Synonym: 4-methoxycinnamic acid, p-methoxycinnamic acid, 3-4-methoxyphenyl acrylic acid, trans-4-methoxycinnamic acid, 4-methoxycinnamate, para-methoxycinnamic acid, o-methyl-p-coumaric acid, cinnamic acid, p-methoxy, e-3-4-methoxyphenyl acrylic acid, e-3-4-methoxyphenyl-2-propenoic acid
• InChI Key: AFDXODALSZRGIH-QPJJXVBHSA-N
• IUPAC Name: (E)-3-(4-methoxyphenyl)prop-2-enoic acid
• PubChem CID: 699414
• Percent Purity: 98%

Safety and Handling

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

H315-H319-H335

missing translation for 'einecsNumber' : 213-405-4

missing translation for 'rtecsNumber' : UD3391300

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : trans-4-Methoxycinnamic acid

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RUO – Research Use Only