Tocris Bioscience™ VH 298

High-affinity inhibitor of VHL

Brand:  Tocris Bioscience™ 6156/10

Product Code. 18721378

Description

VH 298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.

Negative control cis VH 298 also available.

Specifications

• Product Type: Inhibitor
• Molecular Formula: C₂₇H₃₃N₅O₄S
• Content And Storage: Store at -20°C
• Quantity: 10 mg

• Target Proteins: Ubiquitin Ligase (E3)
• Formula Weight: 523.65g/mol
• For Use With (Application): Ubiquitin Ligase (E3) Inhibitors

For Research Use Only