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Tocris Bioscience™ VH 298
High-affinity inhibitor of VHL
£239.00 - £917.00
Specifications
| Product Type | Inhibitor |
|---|---|
| Target Proteins | Ubiquitin Ligase (E3) |
| Molecular Formula | C27H33N5O4S |
| Formula Weight | 523.65g/mol |
| Content And Storage | Store at -20°C |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18721378
|
Tocris Bioscience™
6156/10 |
10 mg |
£239.00
10mg |
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|
18770268
|
Tocris Bioscience™
6156/50 |
50 mg |
£917.00
50mg |
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Description
High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.Negative control cis VH 298 also available.
Specifications
| Inhibitor | |
| C27H33N5O4S | |
| Store at -20°C |
| Ubiquitin Ligase (E3) | |
| 523.65g/mol | |
| Ubiquitin Ligase (E3) Inhibitors |
For Research Use Only
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