VU 10010, Tocris Bioscience™

Description

Selective allosteric potentiator of M4 receptors

Selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.

Specifications

Chemical Identifiers

• CAS: 633283-39-3
• Molecular Formula: C17H16ClN3OS
• Molecular Weight (g/mol): 345.845
• InChI Key: FPRULFHDSFKYBV-UHFFFAOYSA-N
• Synonym: 3-amino-n-4-chlorophenyl methyl-4,6-dimethylthieno 2,3-b pyridine-2-carboxamide, 3-amino-n-4-chlorobenzyl-4,6-dimethylthieno 2,3-b pyridine-2-carboxamide, 2fli, 2-fly, f-ligrlo-nh2, 2-fap, 2-f-ligrlo-nh2, d0n2vn, 2-furoyl-ligrlo-amide trifluoroacetate salt, 2-furoyl-leu-ile-gly-arg-leu-orn-nh2 trifluoroacetate salt
• PubChem CID: 714286
• IUPAC Name: 3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
• SMILES: CC1=CC(=NC2=C1C(=C(S2)C(=O)NCC3=CC=C(C=C3)Cl)N)C

• Quantity: 10 mg
• Formula Weight: 345.85
• Percent Purity: >99%
• Chemical Name or Material: VU 10010