Zoniporide dihydrochloride, Tocris Bioscience™

Description

Selective NHE1 inhibitor

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Specifications

Chemical Identifiers

• CAS: 241799-10-0
• Molecular Formula: C17H18Cl2N6O
• Molecular Weight (g/mol): 393.272
• InChI Key: ARZNPJAGKWHEHT-UHFFFAOYSA-N
• Synonym: zoniporide dihydrochloride, 1-quinolin-5-yl-5-cyclopropyl-1h-pyrazole-4-carbonyl guanidine dihydrochloride
• PubChem CID: 22267855
• IUPAC Name: 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;dihydrochloride
• SMILES: C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N.Cl.Cl

• Quantity: 50 mg
• Formula Weight: 393.27
• Percent Purity: >99%
• Chemical Name or Material: Zoniporide dihydrochloride