General Cell Based Assays
General Cell Based Assays
Thermo Scientific™ LanthaScreen™ STAT3 GripTite™ Cell Line
The JAK/STAT3 signaling pathway is known to be activated by cytokines such as IL-6. In this pathway, binding of IL-6 to its cell-surface receptors results in the activation of JAKs, which in turn phosphoactivate STAT3 proteins at a specific tyrosine residue (Y705).
Thermo Scientific™ Tango™ EDG7-bla U2OS Cells
Tango™ EDG7-bla U2OS cells contain the human Endothelial Differentiation Gene 7 (EDG7) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ GeneBLAzer™ NPSR1-A CHO-K1 DA Assay Kit
The GeneBLAzer™ NPSR1-A CHO-K1 DA (Division Arrested) cells contain the human Neuropeptide S Receptor 1-Isoform A stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Thermo Scientific™ LanthaScreen™ ERK2 U2OS Cell Line
The Map Kinase (MapK) signal transduction cascade is activated by growth factors such as EGF, PDGF, and HGF. Binding of these factors to their respective cell surface receptors results in the initiation of receptor tyrosine kinase activity.
Thermo Scientific™ GeneBLAzer™ PAC1-CRE-bla CHO-K1 Cells
The GeneBLAzer™ PAC1-CRE-bla CHO-K1 cells contain the human Adenylate Cyclase Activating Polypeptide 1 Receptor 1 (ADCYAP1R/PAC1) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.
Thermo Scientific™ LanthaScreen™ IkB alpha GripTite™ Cell Line
The LanthaScreen™ IkB alpha GripTite™ cell line contains a fusion protein consisting of the cDNA encoding for GFP and IkB (GFP is fused to the N-terminus of IkB alpha) under the control of a CMV promoter stably transfected into GripTite™ cells.
Thermo Scientific™ GeneBLAzer™ MCHR2-NFAT-bla CHO-K1 Cells
GeneBLAzer MCHR2-NFAT-bla CHO-K1 cells contain the human melanin-concentrating hormone receptor 2 (GPR145) stably integrated into the CellSensor NFAT-bla CHO-K1 parental cell line.
Thermo Scientific™ GeneBLAzer™ ADRB1-CRE-bla CHO-K1 Cells
The GeneBLAzer ™ ADRB1-CRE-bla CHO-K1 cells contain the human Adrenergic Beta-1 Receptor (ADRB1), (Accession No. NM_000684) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.
Thermo Scientific™ GeneBLAzer™ ADORA3-Gα15-NFAT-bla CHO-K1 cells
GeneBLAzer™ ADORA3-Ga15-NFAT-bla CHO-K1 cells contain the human Adenosine A3 Receptor (ADORA3) stably integrated into the GeneBLAzer™ Ga15-NFAT-bla CHO-K1 cell line.
GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Cells
GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Cells contain the human Cysteinyl receptor (CysLT2).
Thermo Scientific™ GeneBLAzer™ RXR alpha DA Assay Kit
GeneBLAzer™ RXR alpha DA (Division Arrested) cells and RXR alpha-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human retinoid X receptor-alpha (RXR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™ UASbla HEK 293T cell line.
Thermo Scientific™ GeneBLAzer™ PTGIR-CRE-bla CHO-K1 Cells
GeneBLAzer™ PTGIR-CRE-bla CHO-K1 cells contain the human Prostaglandin I2 receptor (IP) (PTGIR), (Accession No. NM_000960.3) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.
Thermo Scientific™ CellSensor™ NFAT-bla Jurkat Cell Line
The CellSensor™ NFAT-bla Jurkat cell line contains a beta-lactamase reporter gene under control of a Nuclear Factor of Activated T Cells (NFAT) response element stably integrated into Jurkat cells.
Thermo Scientific™ Tango™ CCR4-bla U2OS Cells
The Tango™ CCR4-bla U2OS cells contain the human Chemokine (C-C Motif) Receptor 4 (CCR4) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ GeneBLAzer™ CRHR2-CRE-bla CHO-K1 Cells
GeneBLAzer™ CRHR2-CRE-bla CHO-K1 cells contain the human Corticotropin Releasing Factor Receptor 2 (CRHR2) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.