Amiloride hydrochloride dihydrate, Thermo Scientific™

Product Code. 15414599

Brand: Thermo Scientific Alfa Aesar J62168.03

Description

Sodium channel blocker

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Solubility
Soluble in water at 50mg/ml

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 17440-83-4
• Molecular Formula: C6H13Cl2N7O3
• Molecular Weight (g/mol): 302.116
• MDL Number: MFCD00058197
• InChI Key: LTKVFMLMEYCWMK-UHFFFAOYSA-N
• Synonym: amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrateShow MoreShow Less
• PubChem CID: 68540
• ChEBI: CHEBI:2640
• IUPAC Name: 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
• SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

• Quantity: 1g
• UN Number: UN2811
• Merck Index: 14,406
• Solubility Information: Soluble in water at 50mg/ml
• Formula Weight: 266.09
• Chemical Name or Material: Amiloride hydrochloride dihydrate

Seguridad y manipulación

SDS

RUO – Research Use Only