Eurofins DiscoverX BTK (E41K) Protein, Active

Active, N-terminal His6-tagged, recombinant, full-length, human BTK, for use in Kinase Assays.

Brand:  Eurofins DiscoverX 14-773

Product Code. 17360694

Description

BTK (Bruton Tyrosine Kinase) is a non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. BTK also plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway.

GenBank NM_000061

Specifications

• Formulation: mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
• Quantity: 10 μg
• Recombinant: Recombinant
• Expression System: Recombinant protein expressed in Sf21 insect cells
• Purity or Quality Grade: ≥28%

• Molecular Weight (g/mol): 78.4 kDa
• Species: Human
• Protein Tag: N-terminal 6His
• Protein Form: Full-length
• Protein: BTK (E41K), active