STEMCELL Technologies Human Recombinant IL-15, ACF

Interleukin 15, animal component-free

Brand:  STEMCELL Technologies 78218.1

Product Code. 17189871

Description

• Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2
• The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra (the high-affinity receptor for IL-15), as well as IL-2/15Rb (CD122) and common gamma chain (CD132)
• IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells
• Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.) The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways
• IL-15 supports the survival and proliferation of naïve CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells
• IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.) This product is animal component-free

Specifications

• Name: IL-T, Interleukin-15
• Quantity: 100 μg
• Cell Type: Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells
• Purity or Quality Grade: ≥95%