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Tocris Bioscience™ (±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

Brand:  Tocris Bioscience™ 5987/10

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Product Code. 18791068

  • £151.00 / 10mg
Estimated Shipment: 10-04-2025
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Description

Description

(±)-ML 209 is a RORγt inverse agonist (IC50 = 460 nM). Suppresses Th17 cell differentiation and IL17A expression in vitro. Does not suppress transcription of RORα. Minimal activity displayed on ERα, LXRα and thyroid hormone receptors (IC50 values >4.4 μM).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

White
Nuclear Receptor Antagonists
C25H31NO6
Soluble to 100mM in DMSO
Inverse agonism Th17 cell differentiation, inhibits MS multiple sclerosis
Inhibitor
1334526-14-5
441g/mol
Store at -20°C
10 mg
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