SKF 83566 hydrobromide, Tocris Bioscience™

Description

Potent, selective D1-like antagonist

Potent and selective D1-like dopamine receptor antagonist (Ki∽ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.

Specifications

Chemical Identifiers

• CAS: 108179-91-5
• Molecular Formula: C17H19Br2NO
• Molecular Weight (g/mol): 413.153
• InChI Key: SDQJYYGODYRPBR-UHFFFAOYSA-N
• Synonym: skf 83566 hydrobromide, 8-bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1h-benzo d azepin-7-ol hydrobromide, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol hydrobromide, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1h-3-benzazepin-7-olhydrobromide, 8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol hydrobromide, 8-bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol hydrobromide
• PubChem CID: 23581817
• IUPAC Name: 8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrobromide
• SMILES: CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Br.Br

• Quantity: 10 mg
• Formula Weight: 413.15
• Percent Purity: >98%
• Chemical Name or Material: SKF 83566 hydrobromide