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STEMCELL Technologies AKT Inhibitor VIII

PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, and AKT3

Brand:  STEMCELL Technologies 72942

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Product Code. 17110152

  • £193.05 / 1mg

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Description

Description

  • AKT Inhibitor VIII is a cell-permeable, allosteric inhibitor of all three forms of the kinase AKT (AKT1, AKT2, and AKT3) with IC50 values of 58, 210, and 2,200 nM, respectively (Lindsley et al.; Calleja et al.) It displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, such as calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase (Logie et al.)
  • Sensitizes prostate tumor and cervical carcinoma cells to apoptotic stimuli (DeFeo-Jones et al.)
  • Blocks mitosis and inhibits migration of HeLa cells (Jo et al.)
  • Reduces insulin-dependent gene repression in liver cells leading to reduced insulin sensitivity (Logie et al.)
Specifications

Specifications

612847-09-3
1 mg
≥98%
AKTi-1/2; AKT 1/2 inhibitor
C34H29N7O
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