JZP 361, >99%, Tocris Bioscience™

Potent and selective reversible MAGL inhibitor

Brand:  Tocris Bioscience 5851/50

Product Code. 30000842

Description

Potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Specifications

• Chemical Name or Material: [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-
• Purity Grade Notes: >99%
• Quantity: 50 mg
• Formula Weight: 405.88

• CAS: 1680193-80-9
• Linear Formula: C₂₂H₂₀ClN₅O
• Solubility Information: Soluble to 100mM in DMSO and to 20mM in ethanol